Flash chromatography

Flash chromatography

Flash chromatography differs from the conventional technique in two ways: first, slightly smaller silica gel particles (250-400 mesh) are used, and second, due to restricted flow of solvent caused by the small gel particles, pressurized gas (ca. 10-15 psi) is used to drive the solvent through the column of stationary phase. The net result is a rapid over in a flash and high resolution chromatography.